They can be effective for the removal of hyperplastic gingival tissue and result in fast healing with only mild discomfort. Low-level laser therapy (LLLT), [ 39] photobiomodulation diode laser, and dual-wavelength (904/650-nm) laser treatments have been reportedly used as adjuvants in the management of drug-induced gingival hyperplasia The purpose of this paper is to review the causes and describe the appearance of drug-induced gingival overgrowth, so that dental hygienists are better prepared to manage suc h patients. Gingival o vergro wth is caused by three categories of drugs: anticon vulsants, immunosuppressants, and calcium c hannel bloc kers
Drug-induced gingival over growth is a significant considered as the comprehensive treatment of nifedipine-induced gingival enlargement, even in advanced cases. Multiple case reports have demonstrated similar positive induced gingival hyperplasia. A comprehensive review and analysis Gingival hyperplasia is a side effect of certain drugs, including: Cyclosporine — cyclosporine is an immunosuppressant that prevents organ rejection after a heart, kidney, or liver transplant. This drug can also treat dry eyes, rheumatoid arthritis, and psoriasis
Treating gingival hyperplasia often depends on the underlying cause. In many cases, improved oral hygiene can prevent or improve symptoms and resolve this condition. However, if gum overgrowth is a.. Medication-induced gingival hyperplasia is a common condition among patients receiving medications such as nifedipine and phenytoin. Dental providers should be familiar with treatment options for this condition, which are discussed in this systematic review What is drug-induced gingival hyperplasia? Gingival hyperplasia is a condition when the gum tissue becomes enlarged and gingival cells increase in number. First documented in dental literature in 1939 as a side effect of phenytoin, this condition starts with a mild swelling or enlargement that, if left untreated, progresses rapidly
Drugs that may be associated with gingival hyperplasia include: Phenytoin (medication to prevent seizures) Cyclosporine (medication to reduce the activity of your immune system) Calcium channel blockers (medications used to manage cardiovascular conditions Phenytoin is the drug of choice for the treatment of temporal lobe, grand mal, and psychomotor seizures and is the anticonvulsant most associated with gingival enlargements
(Gingival enlargement or gingival overgrowth is the preferred term for all medication-related gingival lesions which were previously termed as gingival hyperplasia. The term gingival hyperplasia, in fact, did not reflect the histopatholgical composition of drug-induced gingival effects) Treatment of drug-induced GO includes surgical and / or non-surgical therapies. Non-surgical treatment, where it is possible, is based on the interruption, modification of the dosage or replacement of the drugs Gingival hyperplasia induced by MIGH drugs is a gingival disorder with a potential impact on aesthetics and chewing function. The available literature on what the best management approach may be is limited, and insufficient evidence to support nonsurgical treatment versus surgical treatment expect to start hearing about many cases of drug-induced gingival overgrowth. Since gingival overgrowth is a drug-induced increase in extra-cellular matrix proteins, the treatment is based on discontinuing the offending medication if at Pre-op view of the maxilla of a five-year-old Wheaton terrier with generalized idiopathic gingival hyperplasia Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases. We analyzed reports of DIGH from SRS databases and calculated the reporting odds ratios (RORs) of.
Gingival hyperplasia typically refers to the increase in the number of cells, whereas gingival hypertrophy deals with the increase in cell size. These microscopic distinctions are both indicative of a disease process. Gingival enlargement can be induced by three main causes stemming from (1) inflammation, (2) medication, and (3) systemic disease The first drug-induced gingival enlargements reported Were those produced by phenytoin (Dilantin). Dilantin is a hydantoin, introduced by Merrill and Putnam80 in 1938 lor the treatment of all forms of epilepsy, except petit maL Shortly thereafter, its relationship with gingival enlargement was reported. View This Abstract Online; Drug-induced gingival hyperplasia, treatment with diode laser. Ann Stomatol (Roma). 2013; 4(Suppl 2):14 (ISSN: 1824-0852). D'Errico B; Albanese The drugs that have been most associated with gingival hyperplasia fall into three categories— anti-seizure medications, immunosuppressant medications used in transplant patients, and calcium channel blockers used to treat various cardiovascular conditions (such as high blood pressure)
Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment. It is being reported with three main groups of drugs like calcium channel blockers (CCBs), immunosuppressants, and anticonvulsants. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10%. by hyperplasia of connective tissue and epithelium. There is acanthosis of the epithelium and deep ep - Treatment of drug-induced gingival enlargement with Er:YAG laser Authors _D B a a Ya a, P G T , B a a 34 I laser 3_2013 use of drug can cause gingival enlargement reexamination regression persistence flap surgery gingivectom Study Design. An electronic literature search was conducted using PICO questions (P = patients with medication-induced gingival hyperplasia; I = surgical and/or nonsurgical treatment options; C = no control is required; and O = partial or complete resolution and recurrence) and medical subject heading terms in the PubMed and Web of Science databases following the Preferred Reporting Items for.
How Drug Induced Gingival Enlargement menifest ? It appears within 1 to 3 months after the use of above mentioned drugs. Drugs induced Gingival Enlargement normally begins at the interdental papilla and gradually appear inflamed or fibrotic in nature .It is confined to the attached gingiva but may extend coronally and interfere with esthetics. Ramakumar and Deepti present a case of gingival hyperplasia associated with diltiazem.1 This condition, more correctly known as drug induced gingival enlargement, is a very common side effect of all calcium channel antagonists, including the dihydropyridines, such as amlodipine, and the non-dihydropyridines, such as diltiazem. The prevalence of drug induced gingival enlargement varies. Gingival overgrowth, also known as gingival hyperplasia, has been well described in the literature. The most recognized cause is drug-induced gingival enlargement from phenytoin (Dilantin), which is commonly used to treat patients with epileptic seizures. Less known drugs that contribute to this phenomenon are Cyclosporine, a potent.
Purpose: This paper identifies 3 specific classifications of commonly prescribed medications that are known to cause gingival enlargement and describes surgical and non-surgical treatment therapies. Primary risks associated with druginduced gingival enlargement, including increased dental decay and periodontal disease are also discussed. The precise bacterial etiology in gingival enlargement. Gingival hyperplasia / hypertrophy is a rather common condition. This article reviews literature pertaining only to gingival overgrowth following drug ingestion. A wide range of causes have been attributed to gingival overgrowth. Drug induced Drug induced gingival enlargement superimposed by inflammation due to local irritating factors as calculus which was treated by scaling , root planning & gin.. Introduction. Drug-induced gingival overgrowth is a common complication of the continuous use of medications, such as anticonvulsant phenytoin, antihypertensive calcium channel blockers (nifedipine), and immunosuppressant cyclosporine-A therapy .Reports about the possible etiological mechanisms of drug-induced gingival overgrowth have been suggested (1, 2, 3) such as an imbalance in collagen.
Because, when it comes to gingival hyperplasia, the treatment depends on the cause. Gingival Hyperplasia Symptoms. These are the most common symptoms of gingival hyperplasia: In the majority of the cases, there is no other symptom than the actual gingival enlargement; When gingival hyperplasia is caused by inadequate oral hygiene, the following. Drug-induced gingival overgrowth is an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medications in the susceptible patient. The gingival overgrowth can be due to three causes: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. . Hygienist must stress the importance of plaque control and spend quality time on oral hygiene instructions. If a patient is on a known medication with this effect it is important to note any gingival changes at each visit Gingival enlargement, an abnormal growth of the periodontal tissue, is mainly associated with dental plaque-related inflammation and drug therapy. Its true incidence in the general population is unknown. Gingival enlargement produces aesthetic changes, pain, gingival bleeding and periodontal disorders.Although gingival overgrowth has been traditionally recognised as an adverse effect of. Non-surgical techniques can limit the occurrence of this unwanted affect, reduce the extent of plaque-induced gingival inflammation and reduce the rate of recurrence. Wherever possible this management strategy should be adopted first. Surgical treatment is often the most reliable option and scalpel gingivectomy remains the treatment of choice
gingival overgrowth and, in rare instances, lymphoma (9). The drug-induced gingival enlargement is a side effect of some immunosuppressive drugs such as cyclosporine A, which is the drug of choice in kidney transplant patients (10). cyclosporin induced gingival overgrowth is more common in pediatri The medication-induced gingival overgrowths occur as a side effect of drugs used mainly for non-dental treatment for which the gingival tissue is not the intended target organ (1, 2). Terms such as gum hypertrophy or gum hyperplasia go hand in hand but they are the histopathological diagnosis of gum enlargement
. Research work is going on to find out the exact mechanism of drug-induced gingival overgrowth, so that once we are clear with its pathogenesis, the treatment modalities can be worked upon. References. References are available in the hard-copy of the website. Drug-induced gingival hyperplasia (DIGH) is a periodontal side effects of certain drugs, causing swelling, bleeding, and problems with chewing, aesthetics, and pronunciation. In more severe cases, it can cause high mobility and detachment of the teeth due to alveolar bone absorption Thus good The first drug-induced gingival enlargements reported communication and cooperative team work among were those produced by Phenytoin. It is a hydantoin, patient, physician and dentist is needed to manage introduced by Merritt and Putnam in 1938 for the drug-induced gingival overgrowths
Gingival enlargement may cause discomfort, interfere with speech or chewing, result in halitosis (bad odour to the breath) and it may look unsightly. What is the treatment for gingival hyperplasia? The treatment depends on the underlying cause Drug-induced gingival hyperplasia was noted in our case with a patient taking oral propranolol for a long duration. A nonselective beta blocker propranolol-induced gingival hyperplasia is a very rare oral drug reaction. According to medsfacts.com, the percentage of propranolol hydrochloride patients where gingival hyperplasia was reported as a. Treatment of Gingival Hyperplasia in Dogs. Treatment of mild gingival hyperplasia is rarely indicated. In more severe or chronic cases, your veterinarian may recommend the following: Discontinuing drug administration if the affected individual is on one of the drugs known to be associated with gingival hyperplasia In cases of drug-induced gingival enlargement, the medication causing the problem should be changed to one that does not induce gingival enlargement. Laser treatment of the enlarged gingival tissues is similar to the technique described above (Figures 6-A, 6-B and 6-C) Gingival hyperplasia can be associated with poor oral hygiene, underlying systemic disease, or as a medication side effect. Oral hygeine may be impaired by developmental disability or poor manual dexterity as a result of stroke, osteoarthritis of the hands, or Alzheimer's disease or other dementia
March, Patricia, Dental Corner: A Boxer with Gingival Hyperplasia, 2013. Niemec, B, Treatment of Gingival Hyperplasia in Dogs, World Small Animal Veterinary Association Congress Proceedings, 2017. Schmidt B R, Glickman N W, DeNichola D B et al (2001) Evaluation of prioxicam for the treatment of oral squamous cell carcinoma in dogs Gingival hyperplasia is a histological (not clinical) term, referring to an abnormal increase in the number of normal cells in a normal arrangement. Gingivectomy and gingivoplasty Gingivectomy and gingivoplasty are surgical procedures designed to remove excess gingiva and to restore its physiological contours Gingival enlargement is also a possible sequel to gingivitis. As in humans, it can be seen as a side effect of the use of ciclosporin. Treatment of gingival hyperplasia. The management of the first line of gingival overgrowth is improved oral hygiene, ensuring that the irritative plaque is removed around the neck of the teeth and gums
Gingival enlargement is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. The treatment is based on the cause Drug-induced Gingival Overgrowth Gingival overgrowth is a well-documented and unwanted side effect, associated principally with the calcium channel blockers, phenytoin and ciclosporin (Table 3-1). The tissue enlargement begins as a painless, beadlike enlargement of the interdental papilla and can extend to involve the buccal and lingual.
treatment of pockets - i.e., gingival sulci that are deepened due to a proliferation or an increase in bulk of gingival tissue in a coronal direction, with or without apical migration of the epithelial attachment. The surgical treatment is the definitive therapy of the drug-induced gingival overgrowth, although the recurrenc Drug induced gingival hyperplasia and it's treatment . Background: Drug induced gingival overgrowth (DIGO) has been traditionally treated with gingivectomy and infrabony defects with flap surgery. Certain authors suggest that recurrence of gingival overgrowth occurs faster after gingivectomy compared to open flap debridement . D'Errico1,A. Albanese2 1Freelancer in Aosta, Italy; 2Department of Surgical, Oncological and Oral Sci-ences, Sector of Oral Medicine V. Margiotta, University of Palermo, Italy Background The present report deals with Er:YAG laser surgical treatment of two patients with drug-induced gingival hyperplasia. We assess the treatment results and follow-ups, and investigate the technique to: (a) maximize the precision of the gingival surgery; (b) control postoperative pain after the excision of the hypertrophic gingival tissue; (c. Drug-induced gingival enlargement is a frequent complication of phenytoin anticonvulsant therapy. In severe cases, gingival hyperplasia can cause marked cosmetic deformity, and significant occlusal changes which severely restrict masticatory function. We describe a unique cas
Gingival overgrowth (GO) was earlier called as gingival hyperplasia or gingival hypertrophy. Drug-induced GO is frequently noticed as a side effect with the use of various medications. Medications that are mainly implicated are anticonvulsants such as phenytoin and calcium channel blockers (CCBs) such a Amlodipine, a newer agent of dihydropyridine derivative, is a third-generation CCB which. The mechanism through which these medications trigger a connective tissue response are still poorly understood. The most effective treatment of drug induced gingival overgrowth is withdrawl or substitution of medication combined with meticulous oral hygiene, plaque control, and removal of local irritants
agents, is excessive gingival growth, with a variation ranging from 13% to 50% [3,4]. Drug-induced gingival hyperplasia (DIGH) represents a real concern, since it may cause swelling, bleeding, alteration of chewing, and pronunciation and aesthetics problems, worsening the patient's quality of life  Gingival hypertrophy is estimated to affect 25% to 81% of patients taking cyclosporine and usually manifests within 6 months of initiation of treatment. 1,2 Other than being an aesthetic concern, cyclosporine-induced gingival hypertrophy can meaningfully limit functional capability, as experienced by this case Treatment for drug induced hyperplasia includes substitution with another drug. Sodium valproate has been used as alternative to dilantin sodium in management of epilepsy. Anti -hypertensives other than calcium channel blockers may be considered for replacement of Nifedipine
Treatment and management of drug induced gingival hyperplasia. Plaque removal; As we have mentioned earlier, dental plaque can worsen your gingival overgrowth condition. The best way to prevent and reduce your gingival swelling if you are taking any of the above drugs is to brush well and remove plaque effectively. Mild gingival enlargement may. Drug-induced gingival overgrowth also called drug-induced gingival enlargement, was previously referred to as drug-induced gingival hyperplasia. It is a noted side-effect of certain drugs given for non-dental uses where the gingival tissue is not the intended target organ effect. Gingival hyperplasia can reach an impressive volume, completely covering the dental crown and affecting the masticatory and physiognomic functions. The elucidation of the mechanism, by which drug-induced gingival hyperplasia occurs, favoring factors and the choice of conservative or surgical treatment Verapamil is an effective prophylactic treatment for cluster headaches and, therefore, is widely used. This report describes four patients with cluster headache who developed gingival enlargement after initiating treatment with verapamil. In two patients, it was possible to control this side effect adequately by optimising oral hygiene and dental plaque control
Currently, the etiology of drug-induced gingival overgrowth is not entirely understood but is clearly multifactorial. Debate is ongoing regarding whether drug-induced gingival overgrowth is due to hyperplasia of the gingival epithelium or of submucosal connective tissue, and/or both. Furthermore, the effect of age, sex, and duration an No periodontal treatment was applied. By 2 months after diagnosis, the patient's thyroid status had returned to normal, and gingival remission was observed (Fig. 2). During a follow-up examination 1 year later, total remission of the gingival hyperplasia was observed (Fig. 3). At that time, periodontal therapy consisted of scaling only The Management of Drug Induced Gingival Hyperplasia in Mentally Retarded Patients with Hemophilia: A Report of Two Cases † James B. Murphy , Fellow in Oral Oncology, Tufts Advanced Education Program in Oral Surgery The clinical therapy for cyclosporine A (CsA)-induced gingival hyperplasia (GH) and the pathological changes in hyperplastic gingival tissues were investigated. Nine cases of CsA-induced GH after renal transplantation were subjected to periodontal non-surgical treatment and surgical treatment and were followed up. Gingival index (GI), dental plaque index (PLI) and GH degree (GHD) at different. Abstract Gingival overgrowth is a well‐documented unwanted effect, associated with phenytoin, cyclosporin. and the calcium channel blockers. The pathogenesis of drug‐induced gingival overgrowth is uncertain, and there appears to be no unifying hypothesis that links together the 3 commonly implicated drugs
2. Drug induced enlargement 3. Enlargement associated with systemic disease 4. Neoplastic enlargement Gingival enlargement is a common finding in clinical practice and the appropriate treatment depends on correctly diagnosing the cause of the enlargement. The most common form of enlargement is due t , Puberty • Drug Induced Hyperplasia - Dilantin, Cyclosporin, Calcium Channel Blockers • Fibromatosis Gingivae • Plasma Cell Gingivitis • Wegener's Granulomatosis • Leukemi
Age, gingival inflammation and attendance at recall visits are all significantly related to recurrence. To help prevent recurrence post-surgically, chlorhexidine rinse twice daily is recommended. Conclusion. Drug-induced gingival enlargement is a common sequela to treatment with anticonvulsants, calcium channel blockers and immunosuppressants Periodontology - Gingival Enlargement. Gingival enlargement is a common characteristic of gingival disease and is manifested as an increase in the size of the gums. Gingival enlargement can be caused by many different factors, and treatment depends on the cause, though hygienic measures are recommended in all cases of gingival enlargement Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug-induced gingival overgrowth. J Clin Periodontol. 2006;33:434-439. 3. Tokgoz B, Sari HI, Yildiz O, et al. Effects of azithromycin on cyclosporine-induced gingival hyperplasia in renal transplant patients. Transplant Proc. 2004; 36:699-702 Drug-induced gingival enlargement has been defined as an increase in gingival tissue size resulting in whole or in part from systemic drug use. 1 Medications usually associated with this condition belong to three different therapeutic classes: calcium channel blockers, immunosuppressants, and anticonvulsants, although rare cases of gingival enlargement have been reported in association with. INTRODUCTIONGingival enlargement is the term now used to describe medication-related gingival overgrowth or gingival hyperplasia and can be defined as an abnormal growth of the periodontal tissue. 1 The term gingival hyperplasia is an inappropriate term because enlargement is not the result of an increase in the number of cells, but rather an increase in extracellular tissue volume. 2.
TREATMENT AT A GLANCE See Aids & Resources,back page,for references,suggested reading,and resources. Article archived on cliniciansbrief.com Cost Key $=<$100 $$=$100-$250 $$$=$250-$500 $$$$=$500-$1000 $$$$$=>$1000 Thermal necrosis in a patient treated for gingi-val hyperplasia using radiosurgery. Generalized bone, soft tissue, and pul Interdisciplinary treatment is becoming an ever-increasing part of modern-day orthodontic practice. This case report details the successful orthodontic-periodontal management of an epileptic patient with a significant drug-induced gingival hyperplasia. The problems that such patient's present are.
Drug-induced gingival enlargement Patients taking certain drugs for existing conditions may be at risk of drug-induce gingival enlargement. In many cases, the condition will respond to non-surgical treatment but in more severe cases modification of the drug regimen by the patient's physician may be considered Abstract: Gingival hyperplasia / hypertrophy is a rather common condition. This article reviews literature pertaining only to gingival overgrowth following drug ingestion. A wide range of causes have been attributed to gingival overgrowth. Drug induced overgrowth commonly occurs following medications prescribed for non dental causes Gingival hyperplasia is the overgrowth of gingiva characterized by the expansion and accumulation of connective tissue with the occasional presence of increased number of cells. There is a variety of causes generating a gingival hyperplasia, starting from a false enlargement to neoplastic, inflammatory, drug-induced Regarding this, which drugs can cause gingival hyperplasia? Drug-induced gingival overgrowth is a side effect associated principally with 3 types of drugs: anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).Also, does Lamictal cause gingival hyperplasia Management of Drug & Inflammation Induced Gingival Enlargement. Gingival hyperplasia or Drug-induced Gingival Overgrowth (DIGO) may be caused by a variety of conditions or prescribed medications and/or therapies, for example, immuno-suppressive therapy (cyclosporin), anticonvulsants (phenytoin) and calcium channel blockers (nifedipine, amlodipine or diltiazem)
Gingival hyperplasia is an excessive growth of the gum tissue. Gingival enlargement or gum disease is often caused by poor hygiene, vitamin C deficiency or due to side effects of prescribed. Gingival hyperplasia and gingival overgrowth result in pseudopockets that trap debris and plaque, commonly resulting in periodontal pocketing. Treatment involves recreating normal anatomy surgically; however, gingival hyperplasia not associated with any specific cause, such as that seen in idiopathic breed-related hyperplasia, will recur in. azithromycin treatment as an adjunctive therapy to oral hygiene measures in reduc-ing drug-induced gingival hyperplasia in renal transplant patients under cyclospo-rine and those under tacrolimus therapy. Material & Methods: Patients diagnosed with early to moderate gingival over-growth with stable allograft function were included in the study Gingival hyperplasia or Gingival enlargement, the currently accepted terminology for an increase in the size of the gingiva, is a common feature of gingival disease. This is strictly a clinical description of the condition and avoids the erroneous pathologic connotations of terms used in the past such as hypertrophic gingivitis or gingival. Gingival enlargement or overgrowth is a common disease of gingiva. The causative factors may range from inflammation due to local factors to conditioned enlargement and neoplastic enlargements. They commonly present as bulbous interdental gingival, diffuse swelling of gingival. Due to the unaesthetic appearance of the overgrown gingiva, treatment becomes inevitable
Gingival hyperplasia is a disease in which the gum tissues overgrow abnormally. Gingival enlargement or hypertrophy are the two other terms used to describe the condition. Gingival Hyperplasia (Gingival Hyperplasias): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis Perio index flaws are that the gingival recession was not taken into account. - Gingival index: each of the 4 gingival areas of the tooth is given a score from 0 (normal) to 3 (severe inflamed), mostly based on color. Score is totaled per tooth or added all together/ (total teeth #) to give GI person score Additionally, is gingival hyperplasia reversible? Gingival hyperplasia is a typical adverse reaction of certain drugs (phenytoin, calcium antagonists and cyclosporine). Drug induced gingival hyperplasia is reversible when the therapy is stopped or modified. If a change of medication is not possible oral hygiene and prophylaxis is critical Home; Books; Search; Support. How-To Tutorials; Suggestions; Machine Translation Editions; Noahs Archive Project; About Us. Terms and Conditions; Get Published.
On the mechanism of drug‐induced gingival hyperplasia On the mechanism of drug‐induced gingival hyperplasia Brown, Ronald S.; Beaver, William T.; Bottomley, William K. 1991-05-01 00:00:00 Proposed mechanisms of the side effect of drug‐induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans. Introduction: Gingival overgrowth or gingival enlargement is a common characteristic of gingival diseases and its most common form is the chronic inflammatory gingival overgrowth .It is exclusively induced by bacterial plaque and its main cause is accumulation and retention of bacteria .In this clinical case, a chronic inflammatory gingival overgrowth and an altered passive eruption.