Home

Intraepidermal blister

Intraepidermal Blisters SpringerLin

Intraepidermal Vesiculopustular Diseases Barnhill's

  1. Histopathologic findings of an early vesicle show intraepidermal acantholysis, which is a loss of adhesion between keratinocytes. Normal skin adjacent to an early blister is ideal for DIF, which shows intercellular IgG and C3 within the epidermis. Serologic studies for IIF should be performed at the same time as the biopsies
  2. INTRODUCTION Friction blisters are intraepidermal blisters caused by the skin repeatedly rubbing on another object. This type of blister most commonly occurs on the hands, fingers, feet, and toes (picture 1A-B). The causes, clinical features, and management of friction blisters will be reviewed here
  3. The histology of herpes infections is very distinctive. The low power pattern of a typical lesion is of an intraepidermal blister (Figure 1). The key feature is acantholysis with solitary keratinocytes within the blister cavity (Figures 1,2,3). Keratinocytes will show nuclear changes in viral infection
  4. Common examples of intraepidermal pustular dermatitis include dermatophytosis, acute generalized exanthematous pustulosis (AGEP), impetigo, and pustular psoriasis. Vesicular skin diseases are characterized by loss of adhesion, either between keratinocytes or along the basement membrane zone
  5. Epidermolysis bullosa (EB) refers to a heterogeneous group of diseases in which the skin and sometimes the mucous membranes blister easily in response to mild trauma, hence the alternative title 'mechanobullous dermatosis', which has sometimes been applied. 1 All are rare conditions; the estimated incidence for the group as a whole is in the order of 1:20 000
  6. Intraepidermal blister is a common clinical symptom following the hypertrophic scar formation. However, little is known about the reason of blister creation. In this study, we selected three patients with hypertrophic scar as manifested by raised, erythematous, pruritic, blister and thickened appearance undergoing scar resection

Intraepidermal Blistering Diseases. Authors. Authors and affiliations. Mosaad Megahed. Mosaad Megahed. 1. 1. Department of Dermatology Heinrich Heine University Düsseldorf Germany. Chapter Intraepidermal blisters may arise in the granular, spinous or suprabasal layers of the skin (Box 87.1). Clinically, blistering within the epidermis presents as thin, flaccid blisters which rupture easily, leading to erosions, scale and crust. Exceptions to this rule are often related to body location. For example, friction blisters occur. Morphologically it is characterized by acantholysis and intraepidermal blister formation. Group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis. Pemphigus is an autoimmune disorder in which your antibodies attack healthy cells in your skin and mouth, causing blisters and sores

In pemphigus vulgaris, acantholysis results in intraepidermal blister with basilar cells aligned at the floor of the blister resembling a row of tombstones (Figs. 4.6 and 4.7). There are no brightly eosinophilic dyskeratotic cells. The roof of the blister shows scalloping of cells due to acantholysis Pemphigus vulgaris is an uncommon, potentially fatal, autoimmune disorder characterized by intraepidermal blisters and extensive erosions on apparently healthy skin and mucous membranes. Diagnosis is by skin biopsy with direct and indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA) testing

Intraepidermal blister located suprabasally with acantholytic cells floating inside the vesicle. The cells of the basal layer remain attached to the basement membrane zone showing a characteristic row of tombstone pattern (hematoxylin-eosin stain; original magnification ×200). (b) Pemphigus vegetans. Acanthosis and pseudoepitheliomatous. Bullous arthropod assault. A. Beneath intraepidermal blistering lies superficial and deep inflammation with extension into fat. B. The vesicle shows spongiotic epidermis at base and multiple eosinophils. C. Eosinophils are prominent in dermal and adipose tissue inflammation. See also. Non-malignant skin disease. Dermatopathology introduction. IgA pemphigus presents as an annular, vesiculopustular eruption characterized by intraepidermal blisters with numerous neutrophils. Intercellular deposits of IgA are present. This entity is also known as intraepidermal neutrophilic IgA dermatosis, intercellular IgA vesiculopustular dermatosis, and intercellular IgA dermatosis.

Blistering skin diseases DermNet N

Bullous pemphigoid blisters are tense and sturdy. 22 They can persist for many days or even weeks, long enough to completely re-epithelialize the base of the blister. Although BP is defined by subepidermal blistering, these re-epithelialized blisters may appear as intraepidermal bullae Friction blisters are intraepidermal blisters caused by the skin repeatedly rubbing on another object. This type of blister most commonly occurs on the hands, fingers, feet, and toes. Friction blisters are a common occurrence in both children and adults. Populations most at risk include individuals whose recreational or occupationalactivities require prolonged walking or running, such as. Intraepidermal and subepidermal blistering with skin. 5 Pages. Intraepidermal and subepidermal blistering with skin. Ana M Abreu Velez. Billie E Jackson. Michael S Howard

Audiotronics 500 > Indigo > Flashcards > Vesiculobullous

Pathology Outlines - Blood bliste

Blistering Disease

  1. C, Histologic specimen showing an intraepidermal blister with acantholysis and a lymphocytic infiltrate (hematoxylin‐eosin, original magnification × 4). D, Sonogram obtained with a 50‐MHz transducer revealing an obvious hyperechoic line at the bottom of the well‐defined anechoic areas
  2. If above that threshold, the intraepidermal tear precipitating blister formation will be the result. Taking into account the words of Sanders et al in their 1995 paper, increased stratum corneum thickness (ie: callous) distributes shear stress over a larger area thereby reducing shear stress gradients and affecting some level of blister prevention
  3. necrotic areas in the epidermis, with both intraepidermal and subepidermal blisters. Dilated dermal blood vessels with a perivascular infiltrate of lymphocytes, histiocytes and neutrophils were seen. DIF revealed anti-stratum corneum reactivity involving multiple immunoglobulins and complement factors, as well as deposits of fibrinogen an
  4. These lesions may vary from case to case and may appear as small, reddened bumps (erythematous macules), non-firm (flaccid) blisters, scaly plaques, pustules, or erosions. Pemphigus IgA, also known as intraepidermal neutrophilic IgA dermatosis, is characterized by the development of fluid-filled blisters on the skin
  5. The term pemphigus refers to a group of autoimmune blistering diseases of skin and mucous membranes that are characterized histologically by intraepidermal blisters due to acantholysis (ie, separation of epidermal cells from each other) and immunopathologically by in vivo bound and circulating immunoglobulin directed against the cell surface of keratinocytes
  6. In bullous pemphigoid, urticarial lesions often precede the development of blisters. In some vesiculobullous diseases such as dermatitis herpetiformis, secondary excoriations may be the only lesions visible, with no intact blisters. Table 10-1. Intraepidermal versus Subepidermal Blisters

Friction blisters - UpToDat

  1. Intraepidermal blister observed by Ko et al. and Rao et al.[5,6] do not explain the scarring. Cell-poor subepidermal blister may be seen in many conditions like epidermolysis bullosa, porphyrias and bullous amyloidosis. To the best of our knowledge, histopathology of early vesicular lesions of lipoid proteinosis that shows cell-poor.
  2. Histologically, both subtypes exhibit intraepidermal blister formation with loss of keratinocytes' adhesion. However, in Pemphigus vulgaris, the split occurs just above the basal cell layer, whereas in pemphigus foliaceus it occurs in the upper part of the epidermis, at the level of the granular layer
  3. ant inflammation, and the patient showed a good response to steroid therapy

Herpes virus infection pathology DermNet N

Histopathology reveals intraepidermal blisters below the granular layer. Edema blisters. These can appear during an acute exacerbation of chronic edema such as occurs with congestive heart failure, acute aggressive fluid resuscitation, and in the setting of anasarca. Blisters are found at the sites of edema Intraepidermal Vesicles. Clinical Presentation: Herpes Simplex (Fig. 5A): Primary infection usually occurs in childhood and may be subclinical with acute gingivostomatitis. Recurrent lesions occur at a similar site each time, usually on the lips, face, or genitalia. Herpes Varicella- Zoster Epidermolysis bullosa simplex (EBS) is a group of hereditary epidermolysis bullosa (HEB) disorders characterized by skin fragility resulting in intraepidermal blisters and erosions that occur either spontaneously or after physical trauma. Onset is usually at or shortly after birth, although blistering in localized EBS may not develop until late. Pemphigus vulgaris is a rare condition that occurs more commonly with increasing age, with a median age of 71. It occurs in women nearly twice as much as in men (2:1) and has a high risk of death. The morphological features characteristic for PF, namely an intraepidermal blister with acantholytic cells in the blister cavity, were readily detectable by means of CLSM. The findings were.

T1 - Use of Skin Biopsy and Skin Blister in Neurologic Practice. AU - Kennedy, William R. AU - Wendelschafer-Crabb, Gwen. AU - Walk, David. PY - 2000/6. Y1 - 2000/6. N2 - Recently developed immunohistochemical methods permit the visualization of intraepidermal nerve fibers (ENFs) in punch skin biopsies and skin blisters This biopsy specimen from the trunk contained a large intraepidermal acantholytic blister (solid arrows). Flanking the blister on both sides was an intense vacuolar-interface dermatitis with. In lesions of several days duration, the blister may appear intraepidermal. Prodromal lesions can show edema of the papillary dermis and a superficial perivascular dermatitis with eosinophils, neutrophils and lymphocytes is usually accompanied by an inflammatory component ( Figure 5 )

intraepidermal: (ĭn″tră-ĕp″ĭ-dĕr′măl) [L. intra , within, + Gr. epi , upon, + derma , skin] Within the epidermis Superficial blisters often manifest as crusted erosions, intraepidermal blisters are often flaccid and may expand under pressure, intra-lamina lucida blisters are often tense and heal with no scarring but sometimes atrophy, sublamina densa blisters usually heal with scarring and milia are often present. Are nails, hair, or teeth involved? III

Epidermolysis bullosa simplex (EBS; intraepidermal skin separation) in EB simplex blisters are formed above the basement membrane*, within the basal keratinocyte of the epidermis. EB simplex usually is associated with little or no extracutaneous involvement, while in others the more severe forms of EB, blisters are not confined to the outer skin Configuration • Grouping of blisters: dermatitis herpetiformis. • String of pearls sign- annular, polycyclic lesions often with blistering around the edge in CBDC 28. NIKOLSKIY SIGN • A positive Nikolskiy sign indicates intraepidermal cleavage and differentiates intraepidermal blisters from subepidermal blisters In concordance with our case, blisters in some studies were intraepidermal in location [6, 7, 10, 11] while in majority of cases, blisters were subepidermal [8, 9]. Bullosis diabeticorum develops usually without inflammatory base, though in our case, lesions were mildly inflamed even in the untouched or unscratched new lesions

Bullous Diseases - Medicine Sms2 with Heymann-lopez at

Kaplan Medical explains why. Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune condition seen in middle-aged to older adults. It is associated with painful, flaccid suprabasal/intraepidermal bullae formation on the skin and oral mucosa. The condition results from formation of IgG directed against epithelial desmosome protein. with clinically obvious intraepidermal blis-ters, but this condition also needs to be dif-ferentiated from pemphigus and other intraepidermal bullous diseases. Both can present as intraepidermal blisters, but the latter occurs in middle-aged and elderly patients, often involving the skin and mucosa.16 Histopathological analysis show Morphologically it is characterized by acantholysis and intraepidermal blister formation; Group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis; Pemphigus is an autoimmune disorder in which your antibodies attack healthy cells in your skin and mouth, causing blisters and sores Bullae are initially subepidermal, and then intraepidermal blisters repre­sent older lesions undergoing re-epithelialization. Interestingly, the adjacent epidermis is often unremarkable. The dermis shows minimal inflammation, and microvascular changes consistent with diabetes are also present. The proteinaceous fluid contained in bullae is. Bulla(e) A larger fluid-filled blister within the epidermis (intraepidermal blister) or below it (subepidermal blister). See also vesicle, below. [web.archive.org] Small blisters are called vesicles. Calcinosis cutis Calcinosis cutis refers to deposition of calcium in the skin

Dermatopathology 101: Part 1 - Inflammatory skin diseases

  1. Hand-foot skin reaction is distinct from the hand-foot syndrome (HFS). HFS, also known as palmar-plantar erythrodysesthesia, is associated with chemotherapy agents such as 5-fluorouracil and capecitabine. 1 HFS presents with diffuse painful oedema and redness of palms and soles. Whereas HFSR is dose-dependent and characteristically localizes to.
  2. Case #1. Pemphigus vulgaris (PV) is an autoimmune bullous disease characterized clinically by flaccid blisters and erosions on the skin and mucous membranes, and histologically by acantholysis. 1.
  3. intraepidermal blisters and autoimmune condition. Circuting acantholytic antibodies against desmoglein 1 (st. granulosum, mucosa rarely involved, P. foliaceus) or desmoglein 3 (suprabasal, P. vulgaris) causing acntholysis (separation of cells by failure of desmosomes). Can also be due to a tumor and paraneoplastic consequences of IL-6
  4. A blistering skin disorder. Morphologically it is characterized by acantholysis and intraepidermal blister formation. Definition (CSP) group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis. Definition (MSH
  5. Both can present as intraepidermal blisters, but the latter occurs in middle-aged and elderly patients, often involving the skin and mucosa. 16 Histopathological analysis shows the loss of adhesion between keratinocytes (acantholysis), immunopathological findings in skin lesions and blood circulation of IgG antibodiesy. Hyperkeratosis.
  6. A blister, in this sense, is a lesion of the skin which is generated as a defense method developed by the body. It is a reaction that the body makes to a friction or one burn, in order to restore the skin. Blisters form from a build-up of lymphatic fluid and other fluids. As the skin widens, the wound is protected

Inherited and autoimmune subepidermal blistering diseases

5. • Definition: Nikolsky's sign refers to the ability to induce peripheral extension of a blister as a consequence of applying lateral pressure to the border of an intact blister. • Indication to perform oTo differentiate intraepidermal from subepidermal blister. 6 Intraepidermal blisters Epidermis Dermis. Summary. Findings Note that inflammatory edema has loosened the epidermal cells with formation of intraepidermal blisters. Impression Herpes zoster, intraepidermal blisters. Preparation Fixed, H & E stain. View Light micrograph. Specimen Ski •Blisters mainly arising on the dorsa of the hands (sometimes on the face) (predominantly on light-exposed areas) •Combination of sun exposure and minor trauma •The skin of the face and dorsa of the hands often are thickened and sclerotic intraepidermal neutrophil herpetiform clustering of intraepidermal blisters and a marked degree of pa mo- plantar hyperkeratosis. Only sporadic clinical reports have been published so far in the literature. We review here, the clinical features of 22 of our patients affected with DM-EB ( 13 males and 9 females) ranging from birth to age 5 The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation

Involvement of impaired desmosome-related proteins in

), on blister formation induced by F779-IgA1 mAb was assessed in the cryosection model. Cryosections of human skin were exposed to F779-IgA1 mAb pre-incubated with different doses of peptide M (50, 25, 5, 1 and 0.5 μg; in a total volume of 50 μL/skin section) for 1 h at 37°C and then the assay was carried out as described above and in. Reactions 1607, p423 - 25 Jun 2016 Intraepidermal blister with acantholytic dyskeratosis: case report A 69-year-old man developed intra-epidermal blister with acantholytic dyskeratosis during treatment with vemurafenib. The man with the diagnosis of nodular melanoma was started on vemurafenib 960mg twice daily [route not stated]. He developed a pruritic, maculopapular exanthema, confluent on. Suprabasilar acantholysis; intraepidermal blister formation; tomb-stoning on pathology (Meg) Pemphigus vulgaris DIF: IgG in a chicken-wire pattern through the epidermis (Meg) Pemphigus vulgaris Upper epidermal acantholysis (within or adjacent to granular layer) (Meg) Pemphigus foliaceous DIF: IgG in a chicken-wire pattern predominantly in the. Also called intraepidermal neutrophilic IgA dermatosis, this autoimmune blistering disease covers the skin with fluid-filled blisters. Upper arms and legs are most typically affected while the mucous membranes - like the eyes, nose, and mouth - remain blemish-free

Pathology And Anatomical Science Who Knows > Heck

Other causes of subcorneal and intraepidermal blistering. Bullous impetigo . This is a common cause of blistering in children. The bullae are flaccid, often contain pus and are frequently grouped or located in body folds. Bullous impetigo is caused by Staphylococcus aureus. Scalded skin syndrom Types of Autoimmune Blistering Skin Diseases Autoimmune blistering skin diseases include: Pemphigus: A group of intraepidermal blistering disorders that cause erosions and/or sores on the skin, mouth, throat, nose, eyes, scalp, or genitals (includes pemphigus vulgaris and pemphigus foliaceous); Pemphigoid: A group of subepidermal blistering disorders that cause vesicles, blisters, erosions. • Blister formation in skin graft donor or recipient sites is uncommon. We describe a 49-year-old female patient with bullae in sites of grafts used in the treatment of toxic epidermal necrolysis. Generalized loss of skin developed 3 weeks after she had ingested phenobarbital. Sixty days after the..

Bullous involvement complicates erysipelas in some 5% of cases, with flaccid intraepidermal sterile blisters. The bullous form tends to occur more frequently among women and people with liver or renal disease. Those with bullous lesions have increased rates of infection with MRSA,. Kindler syndrome blisters can form in the intraepidermal or subepidermal level. Different types have different inheritance patterns. (See table Some Features of the Major Epidermolysis Bullosa Types.) Epidermolysis bullosa simplex is the most common and mildest type, occurring in about 80% of cases

Pathology Outlines - Vesiculobullous and acantholyticCobblestone mouth: An exuberant oral presentation of

Intraepidermal Blistering Diseases SpringerLin

The term pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized histologically by intraepidermal blister and immunopathologically by the finding of in vivo bound and circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes This is the set-up for high shear stresses in the skin, intraepidermal delamination (tears in the stratum spinosum of the epidermis) and the formation of blisters. This half explains my assertion that moleskin doesn't reduce friction levels, and in fact, increases them Again it is an intraepidermal pustule with neutrophils, occasionally with some eosinophils and it can subsequently go up to be a subcorneal pustule. There are no bacteria or fungi seen and often it is difficult to visualise any scabies mite either. This problem can persist after infantile scabies has been cured Approximately 1 month ago my 7 year old son came down with what I thought at the time was a mosquito bite on his face- which he then picked (or so I thought). About 2 days after this sore on his cheek, he broke out with a few more blister-like sores on his chest, a couple more on his face/neck, and arms and leg. (In all around 20 or so blisters)

87 Differential Diagnosis of Vesiculobullous Lesions

Multiple Bullae on the Trunk - Photo Quiz - American

2021 ICD-10-CM Diagnosis Code L10

Blistering Disorders and Acantholytic Processes Affecting

Summary. Autoimmune blistering diseases are skin conditions characterized by the formation of blisters, which are the result of the destruction of cellular or extracellular adhesion molecules by antibodies.The three most significant autoimmune blistering diseases are bullous pemphigoid, pemphigus vulgaris, and dermatitis herpetiformis.The most common among these is bullous pemphigoid, which. This scFv consistently leads to the induction of intraepidermal blister formation when injected into normal human skin (Figure 5). In the presence of the anti-Dsg1/3 scFv, intraepidermal splits were present in the skin specimen, while injection of NH IgG (NC) left the skin intact intracellular attachments, and formation of intraepidermal blisters.9 Historically, use of cotton swabs and other non-specific applicators to administer cantharidin has led to placement of drug beyond the intended papules, leading in some instances to robust blistering and discomfort. Of note, since the action of cantharidin is largely. Autoimmune bullous diseases are often associated with significant morbidity and some can even cause mortality, if left untreated. Multiple therapies are now available to treat these blistering. Friction blisters are intraepidermal blisters caused by the skin repeatedly rubbing on another object. This type of blister most commonly... July 10, 2021 Ozonated Oil to Treat Stasis Dermatitis. Stasis dermatitis, or stasis eczema, is a common inflammatory dermatosis of the lower extremities occurring in patients with chronic.

Pemphigus Vulgaris - Dermatologic Disorders - Merck

Q 21. intraepidermal acantholytic blister is seen in all except pemphigus vulgaris paraneoplastic pemphigus dermatitis herpetiformis epidermolysis bullosa. Q 22. which layer of skin causes vesicular change in case of burns basal layer papillary layer epidermis dermis The pathologist looks for an intraepidermal vesicle caused by the breaking apart of epidermal cells (acantholysis). Thus, the superficial (upper) portion of the epidermis sloughs off, leaving the bottom layer of cells on the floor of the blister. This bottom layer of cells is said to have a tombstone appearance Key features: Grouped blisters with crusts in the epidermis when autoantibodies attack desmocollin 1. Subtypes: Subcorneal pustular dermatosis-type IgA pemphigus (Sneddon-Wilkinson disease), intraepidermal neutrophilic IgA dermatosis. The subcorneal pustular dermatosis type of IgA pemphigus is clinically similar to Sneddon-Wilkinson disease Two days later, multiple tense hemorrhagic blisters with normal-appearing adjacent skin appeared on the patient's extremities (fig. 1). A skin biopsy was performed and revealed an intraepidermal (subcorneal) blister and partially to frankly necrotic epidermis with a mild inflammatory infiltrate in the adjacent dermis (fig. 2) Intraepidermal tonofilaments- K5, 14 Blisters in areas prone to traum

Histological and Immunofluorescence Diagnosis of

Tzanck smear from skin lesions done in 5 patients were positive. The diagnosis of pemphigus vulgaris is based on 3 independent sets of criteria: clinical features, histology and immunological tests. (14) Histologically, there is an intraepidermal blister associated with acantholytic cells. DIF is diagnostic in almost 100% cases Friction blisters. . Friction blisters are intraepidermal blisters caused by the skin repeatedly rubbing on another object. This type of blister most commonly occurs on the hands, fingers, feet, and toes The causes, clinical . ›. Treatment of minor thermal burns. View in Chinese. detail separately. Blisters may develop with.

Bullous diseases - Libre Patholog

Cantharidin. Cantharidin is a fatty substance of the terpenoid class produced by beetles belonging to the order Coleoptera and the family Meloidae, otherwise known as blister beetles. 9 When epidermal cells absorb cantharidin, serine proteases are released, which cause the breakdown of the desmosomal plaque, part of the anchorage structure of cells; loss of intracellular attachments; and the. Intraepidermal blisters (b) but lack of partial dermoepidermal separation. Better quality of graft take and minimal rejection response than in control group B. Figure 17. Formalin fixed, paraffin embedded homologous FTSG x200 in group b. Inflammatory response with concentrations of eosinophils (e), lymphocytes (l) and polymorphonuclear cells (p. Pemphigus is an autoimmune blistering disease which is characterized histologically by intraepidermal blisters due to separation of epidermal cell-cell contacts, and immunopathologically by circulating IgG type autoantibodies directed against the desmosomes, which is the cell-cell attachment device in the epidermis. This review briefly summarizes current concepts of conventional diagnosis and. A positive Nikolskiy sign indicates intraepidermal cleavage and differentiates intraepidermal blisters from subepidermal blisters. 2 It is pathognomonic of pemphigus and staphylococcal scalded skin syndrome. The sign may also be elicitable in the rare ichthyosis bullosa of Siemens, where it is. Ultrastructural investigation of a fresh blister and clinically intact preblistering skin revealed intraepidermal blister formation via cytolysis of basal cells, preceded by clumping of tonofilaments and partial attachment to the hemidesmosomes at the dermo-epidermal junction. This type of blister formation was significantly different from all.

The four major types of EB (with the site of blister separation) are epidermolysis bullosa simplex (EBS; intraepidermal cleavage), junctional epidermolysis bullosa (JEB; within the lamina lucida of the basement membrane), dystrophic epidermolysis bullosa (DEB; sublamina densa, upper dermis), and Kindler epidermolysis bullosa (KEB; basal. Figure 2 Intraepidermal blister displaying ballooning and acantholytic keratinocytes and multinucleated cells with nuclear molding. (A) Fibrinoid necrosis (arrow) and thrombosis (arrowhead) of vessels of the hypodermis. (B) Hematoxylin and eosin stain; ×200 original magnification These lesions commonly affect the scalp and manifest as blisters, erosions and crustations. Pemphigus is a group of potentially life-threatening intraepidermal vesiculobullous autoimmune diseases that affect the skin and mucous membranes